Key result
Higher serum adiponectin levels were independently associated with a lower risk of aortic stiffness in elderly diabetic persons (OR 0.939; 95% CI 0.898-0.981; p=0.005).
Why the study?
Aortic stiffness is a common manifestation of atherosclerosis in elderly diabetic patients, and whether low serum adiponectin levels are associated with it remained to be evaluated.
Are low serum adiponectin levels associated with aortic stiffness in elderly diabetic patients?
Cross-Sectional (n=130)
Are low serum adiponectin levels associated with aortic stiffness in elderly diabetic patients?
Odds Ratio: 0.939 (95% CI 0.898–0.981)
p-value: p=0.005
Lower serum adiponectin levels are independently associated with increased aortic stiffness in elderly diabetic patients, suggesting a potential biomarker for vascular risk.
Low adiponectin may mark vascular risk in geriatric diabetes; hypothesis-generating, prospective studies needed before clinical use.
Adiponectin has anti-inflammatory activity against atherosclerosis. Aortic stiffness is a common manifestation of atherosclerosis in diabetes mellitus and elderly persons. This study aimed to evaluate whether low serum adiponectin levels were associated with aortic stiffness in geriatric diabetic patients. Blood samples were obtained from 130 diabetic participants aged ≥ 65 years. We defined high aortic stiffness based on a carotid−femoral pulse wave velocity (cfPWV) of >10 m/s. Circulating adiponectin concentrations were examined using enzyme-linked immunosorbent assays. Sixty-six participants (50.8%) had aortic stiffness. Patients with aortic stiffness had lower serum adiponectin concentrations than those in the control group (p < 0.001). Multivariate logistic regression analysis showed that the adiponectin level (odds ratio: 0.939, 95% confidence interval: 0.898−0.981, p = 0.005) was an independent predictor of aortic stiffness in elderly diabetic persons. Multivariate forward stepwise linear regression analysis also demonstrated that the adiponectin level (β = −0.256, adjusted R2 change = 0.100, p = 0.003) was negatively associated with cfPWV values in older diabetic patients. In conclusion, serum adiponectin is negatively correlated with cfPWV and is an independent predictor of aortic stiffness in elderly diabetic persons.
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Hung et al. (2022) conducted a cross-sectional in Diabetes mellitus (n=130). Serum adiponectin level was evaluated on Aortic stiffness (carotid−femoral pulse wave velocity >10 m/s) (OR 0.939, 95% CI 0.898-0.981, p=0.005). Higher serum adiponectin levels were independently associated with a lower risk of aortic stiffness in elderly diabetic persons (OR 0.939; 95% CI 0.898-0.981; p=0.005).
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