The influence of the administration of arginine and histidine on the excretion of creatinine

THE numerous attempts to demonstrate the origin of muscle-creatine or urinary creatinine from arginine or histidine have been almost entirely negative in result or open to serious criticism. The fact that both arginine and histidine are subject to destruction by the liver has no doubt militated against any positive result in the majority of cases, especially when small amounts of the amino-acids have been administered per os.