Key result
In non-anticoagulated patients undergoing hemodialysis, atrial fibrillation was independently associated with an increased risk of all-cause death (HR 1.82) but not ischemic stroke.
Why the study?
Does atrial fibrillation increase the risk of ischemic stroke and death in non-anticoagulated patients undergoing hemodialysis?
Cohort (n=380)
No
Does atrial fibrillation increase the risk of ischemic stroke and death in non-anticoagulated patients undergoing hemodialysis?
Hazard Ratio: 1.82 (95% CI 1.12–2.94)
Absolute Event Rate: 15.75% vs 6.35%
p-value: p=0.014
In non-anticoagulated hemodialysis patients, atrial fibrillation is associated with a significantly increased risk of all-cause death, but not a statistically significant increase in ischemic stroke or major bleeding.
Outcomes in non-anticoagulated AF on hemodialysis remain understudied; leaves open optimal anticoagulation strategies in this population.
Objective The progress of non-anticoagulated patients with atrial fibrillation (AF) undergoing hemodialysis has not been determined. Using data from the RAKUEN (Registry of Atrial fibrillation in chronic Kidney disease Under hEmodialysis from Niigata) study, we examined the clinical characteristics and outcomes among hemodialysis patients with AF who were not receiving a vitamin K antagonist (VKA). Methods and Results Forty-three of 423 patients undergoing hemodialysis (-10%) were prescribed a VKA. The remaining 380 patients (age 64.8±12.8 years, male 70%) were enrolled in the present study. During a mean observation period of 36 months, AF (n=55) was independently associated with all-cause death (hazard ratio, 1.82; 95% confidence interval, 1.12-2.94; p=0.014), but was not associated with ischemic stroke (hazard ratio, 1.91; 95% confidence interval, 0.74-4.92; p=0.177) and major bleeding (hazard ratio, 1.80; 95% confidence interval, 0.80-4.08; p=0.150). The crude incidence rates of all-cause death and ischemic stroke in the AF patients were 15.75 (2.5-fold higher compared to the non-AF patients) and 3.63 (1.7-fold higher compared to the non-AF patients) per 100 person-years, respectively. Conclusion A great impact on death, but not ischemic stroke, was observed in non-anticoagulated hemodialysis patients with AF in comparison to those without AF from the analysis of the RAKUEN study.
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Mitsuma et al. (2018) conducted a cohort in End-stage renal disease on hemodialysis (n=380). Atrial fibrillation vs. No atrial fibrillation was evaluated on All-cause death (HR 1.82, 95% CI 1.12-2.94, p=0.014). In non-anticoagulated patients undergoing hemodialysis, atrial fibrillation was independently associated with an increased risk of all-cause death (HR 1.82) but not ischemic stroke.
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