Key result
Atrial fibrillation in hemodialysis patients was independently associated with increased all-cause mortality (HR 1.32; 95% CI 1.02-1.71) and cardiovascular events, but not stroke.
Why the study?
Does atrial fibrillation increase the risk of mortality, cardiovascular events, and stroke in Japanese hemodialysis patients?
Cohort (n=7,002)
Yes
Does atrial fibrillation increase the risk of mortality, cardiovascular events, and stroke in Japanese hemodialysis patients?
Hazard Ratio: 1.32 (95% CI 1.02–1.71)
In Japanese hemodialysis patients, atrial fibrillation is associated with increased mortality and cardiovascular events, but unexpectedly not with an increased risk of stroke.
AF incidence data in hemodialysis supports screening vigilance; leaves open outcome and management implications.
Atrial fibrillation is one of the most common arrhythmias in hemodialysis patients. We evaluated its clinical outcomes among hemodialysis patients with atrial fibrillation in Japan. Using data derived from the Japanese Dialysis Outcomes and Practice Patterns Study, we analyzed backgrounds and outcomes among hemodialysis patients with and without atrial fibrillation in Japan. Among 7002 hemodialysis patients, the prevalence of atrial fibrillation was 5.7% and the incidence was 0.2 per 100 patient-years. Atrial fibrillation was independently associated with all-cause mortality (hazard ratio, 1.32; 95% confidence interval, 1.02-1.71) and cardiovascular events (hazard ratio, 1.39; 95% confidence interval, 1.15-1.68), but not with stroke events (hazard ratio, 0.77; 95% confidence interval, 0.55-1.06) after adjustment for other variables. We conclude that patients with atrial fibrillation experienced higher mortality and more cardiovascular events than did patients without atrial fibrillation, although the risk of stroke was lower than expected.
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Hasegawa et al. (2016) conducted a cohort in Hemodialysis (n=7,002). Atrial fibrillation vs. Without atrial fibrillation was evaluated on All-cause mortality (HR 1.32, 95% CI 1.02-1.71). Atrial fibrillation in hemodialysis patients was independently associated with increased all-cause mortality (HR 1.32; 95% CI 1.02-1.71) and cardiovascular events, but not stroke.
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