Key result
Exercise training significantly reduced the incidence of positive left ventricular remodeling to 26.6% compared to 52.6% in the control group at 6 months in male patients following acute STEMI.
Why the study?
To investigate the effect of exercise training on left ventricular systolic function and left ventricular remodeling, and to study potential mechanisms involving MMP-9 and TIMP-1 in patients with acute STEMI.
Does individualized exercise training prevent left ventricular remodeling in patients with acute STEMI?
Population
Patients with acute STEMI
Comparison
Exercise group vs control group
Follow-up
6 mo
Authors
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May support early ET post-AMI; leaves open effects on LVRM pending larger trials.
RCT (n=60)
Single-blind
1:1 ratio
No
Does individualized exercise training prevent left ventricular remodeling in patients with acute STEMI?
Absolute Event Rate: 26.6% vs 52.6%
p-value: p=<0.01
Early home-based exercise training after STEMI improves cardiopulmonary function and reduces left ventricular remodeling, potentially by modulating MMP-9 and TIMP-1 levels.
Cai et al. (2021) conducted an RCT in Acute ST-segment elevation myocardial infarction (STEMI) (n=60). Exercise training vs. No rehabilitation exercise guidance was evaluated on Positive left ventricular remodeling (LVRM) at 6 months (p=<0.01). Exercise training significantly reduced the incidence of positive left ventricular remodeling to 26.6% compared to 52.6% in the control group at 6 months in male patients following acute STEMI.
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