Why the study?
Do selective serotonin reuptake inhibitors (SSRIs) improve symptoms in patients with panic disorder compared to placebo or TCAs?
Population
Patients with panic disorder, as well as animal and laboratory models
Comparison
Selective serotonin reuptake inhibitors (SSRIs) vs Tricyclic antidepressants, placebo, and other…
Design
Review
Authors
Discussion
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Member takes
Implication
May support SSRI preference in panic disorder; leaves open need for updated RCTs versus TCAs.
Structured PICO
Do selective serotonin reuptake inhibitors (SSRIs) improve symptoms in patients with panic disorder compared to placebo or TCAs?
P
Population
Patients with panic disorder, as well as animal and laboratory models
I
Intervention
Selective serotonin reuptake inhibitors (SSRIs)
C
Comparator
Tricyclic antidepressants (TCAs), placebo, and other serotonergic agents
O
Outcome
Improvement in panic disorder symptoms
SSRIs are an effective and better-tolerated alternative to TCAs for the treatment of panic disorder, highlighting the complex role of serotonin in anxiety.
Cite This Study
Bell et al. (1998) studied this question.