Key result
Short 7-day imipramine, paroxetine, and sertraline reduce CO2 reactivity vs placebo in panic patients.
Why the study?
The effects of short-term treatment with imipramine, paroxetine, and sertraline on reactivity to 35% CO2 inhalation in panic patients were unclear.
Does short treatment with imipramine, paroxetine, or sertraline reduce reactivity to 35% CO2 in panic patients?
RCT (n=70)
Double-blind
random
Does short treatment with imipramine, paroxetine, or sertraline reduce reactivity to 35% CO2 in panic patients?
Short treatment (7 days) with imipramine, paroxetine, or sertraline decreases reactivity to 35% CO2 in panic patients, suggesting early antipanic properties.
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Indicates potential rapid antipanic effects of these agents; extends CO2 challenge as a biomarker for early treatment response in panic disorder.
Bertani et al. (1997) conducted an RCT in Panic disorder (n=70). Imipramine, paroxetine, and sertraline vs. Placebo was evaluated on Reactivity to inhalation of 35% CO2/65% O2. Short 7-day treatments with imipramine, paroxetine, and sertraline significantly decreased reactivity to 35% CO2 compared to placebo in panic patients.
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