Key result
Paroxetine increases the rate of meaningful CO2 reactivity reduction by ~233% vs reboxetine.
Why the study?
The relative effects of short-term treatment with paroxetine versus reboxetine on CO2 hyperreactivity in patients with Panic Disorder were unclear.
Does paroxetine reduce anxiety reactivity to 35% CO2 more than reboxetine in patients with Panic Disorder?
RCT (n=28)
Double-blind
randomized
Does paroxetine reduce anxiety reactivity to 35% CO2 more than reboxetine in patients with Panic Disorder?
Absolute Event Rate: 71.5% vs 21.5%
Short-term treatment with paroxetine is more effective than reboxetine in reducing CO2 hyperreactivity in panic disorder, suggesting serotonergic modulation is more relevant than noradrenergic modulation.
Supports paroxetine over reboxetine for CO2 hyperreactivity in panic disorder; confirms serotonergic superiority in this RCT model.
The effects of short treatments (7 days) with paroxetine and with reboxetine on the reactivity to inhalations of 35% carbon dioxide (CO2)/65% oxygen (O2) were compared in 28 patients with Panic Disorder who had positive responses to 35% CO2 inhalations. A double-blind, randomized design was applied. Each patient was given the 35% CO2 challenge on days 0 (before starting the treatment) and 7. Anxiety reactivity to CO2 decreased significantly with both drugs but the decrease was significantly stronger in the group treated with paroxetine. The rate of patients whose reactivity has reduced of at least 50% after 7 days was significantly higher in the group treated with paroxetine (10/14, 71.5%) than in the one treated with reboxetine (3/14, 21.5%). These results indicate that the modulation of the serotonergic system is more relevant for CO2 hyperreactivity than the modulation of the noradrenergic one.
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Perna et al. (2004) conducted an RCT in Panic Disorder (n=28). Paroxetine vs. Reboxetine was evaluated on Reduction of anxiety reactivity to CO2 of at least 50% after 7 days.
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