Randomized clinical trial shows decreased hypercapnic ventilation in individuals taking SSRIs with oxycodone, suggesting a shared effect.
Both paroxetine and escitalopram, alone and co-administered with oxycodone, decrease hypercapnic ventilation after 21 days suggesting that selective serotonin reuptake inhibitors may have a class effect on hypercapnic ventilation that persists with chronic use.
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Florian et al. (2026) studied this question.
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