Why the study?
Does reduced circadian blood pressure variation independently predict mortality or ESRD in elderly veterans with or without CKD?
Population
322 elderly veterans, 179 (56%) of whom had chronic kidney disease (CKD)
Comparison
Reduced circadian blood pressure variation vs Normal circadian blood pressure variation
Design
Cohort
Follow-up
up to 8.7 years
Authors
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Non-dipping should not yet guide risk assessment in elderly veterans; leaves open whether circadian BP variation independently predicts mortality or ESRD.
Does reduced circadian blood pressure variation independently predict mortality or ESRD in elderly veterans with or without CKD?
Circadian blood pressure variation is associated with mortality in elderly veterans, but this association is abolished after accounting for age and 24-hour average systolic BP.
Agarwal et al. (2009) studied this question.
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