Key result
Analysis of G12P[8] rotavirus genomes from children with diarrhea revealed multiple introductions and sequence polymorphisms predicting antigenic mismatch with vaccine strains.
Observational
No
Antigenic mismatch between emerging G12P[8] rotaviruses and vaccine strains may contribute to their increased predominance, highlighting the need for continued monitoring of vaccine effectiveness.
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Multiple G12 introductions detected locally; leaves open drivers of global spread and vaccine impact.
Ogden et al. (2018) conducted an observational in Childhood diarrheal disease (Rotavirus). G12P[8] rotavirus vs. Vaccine strains was evaluated on Genomic sequence polymorphisms and antigenic mismatch. Analysis of G12P[8] rotavirus genomes from children with diarrhea revealed multiple introductions and sequence polymorphisms predicting antigenic mismatch with vaccine strains.