Key result
Antigen shift among epidemiologically major G1P[8] rotavirus strains was observed in 6 seasons over a 16-year period in Hungary, indicating a dynamic nature for these common strains.
Observational
The study highlights the dynamic nature of G1P[8] rotavirus strains in Hungary over 16 years, emphasizing the need for international strain surveillance.
Supports intensified rotavirus strain surveillance; leaves open whether shifts affect vaccine performance.
Epidemiological trends of the globally most common rotavirus genotype, G1P[8], were investigated in Hungary during a 16-year period by sequencing and phylogenetic analysis of the surface antigens. Antigen shift among epidemiologically major G1P[8] strains was observed in 6 seasons, as indicated by changes in the sublineages of the G1 VP7 and the P[8] VP4 genes. The temporal clustering of some rotavirus VP4 and VP7 gene sublineages and the periodic emergence and/or resurgence of previously unrecognized rotavirus sublineages in the study population suggest a dynamic nature for these common strains. Recently established international strain surveillance networks may help to identify and track the spread of epidemiologically important rotavirus strains across countries and continents.
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Bànyai et al. (2009) conducted an observational in Human G1P[8] Rotaviruses. Human G1P[8] Rotaviruses was evaluated on Epidemiological trends and antigen shift of G1P[8] strains. Antigen shift among epidemiologically major G1P[8] rotavirus strains was observed in 6 seasons over a 16-year period in Hungary, indicating a dynamic nature for these common strains.
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