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May 4, 2015PLoS ONEOpen Access

Whole Genomic Analysis of Human G12P6 and G12P8 Rotavirus Strains that Have Emerged in Myanmar

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Key result

Whole genomic analysis of six G12 rotavirus strains from Myanmar revealed a Wa-like genetic backbone, with five strains sharing a common origin and one showing evidence of human-bovine reassortment.

Population

6 stool samples containing G12 rotavirus strains from children with acute gastroenteritis in Myanmar

Design

Other

Authors

TITomihiko IdeFujita Health UniversitySKSatoshi KomotoOkayama Shoka UniversityKHKyoko Higo‐MoriguchiFujita Health University

Discussion

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Member takes

Implication

Genomic surveillance of emerging G12 strains remains essential in Asia; leaves open effects on current vaccine performance.

Structured PICO

P
Population
6 children with acute gastroenteritis in Myanmar whose stool samples contained G12 rotavirus strains.
E
Exposure
Whole genome sequencing and phylogenetic analysis
O
Outcome
Genomic characterization and phylogenetic relationships of the 11 gene segments

Whole genome sequencing of emerging G12 rotavirus strains in Myanmar reveals multiple distinct origins, including potential human-bovine reassortment, highlighting the complex evolutionary dynamics of rotaviruses in Asia.

Limitations

  • Small sample size of only six fully sequenced strains
  • Exact origin of the NSP4 gene of strain A23 could not be ascertained due to a lack of a sufficient number of representative strains as references

Cite This Study

Ide et al. (2015) studied Acute gastroenteritis (Rotavirus infection) (n=6). G12 rotavirus strains was evaluated on Genomic constellation and phylogenetic relationships. Whole genomic analysis of six G12 rotavirus strains from Myanmar revealed a Wa-like genetic backbone, with five strains sharing a common origin and one showing evidence of human-bovine reassortment.

synapsesocial.com/papers/6a7b92d34fcef545fadf767bhttps://doi.org/10.1371/journal.pone.0124965
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular Epidemiology of Rotavirus Diarrhea among Children Aged <5 Years in Nepal: Predominance of Emergent G12 Strains during 2 Years2009 · 51 citations
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  3. 3Genetic diversity of group a rotavirus isolates found in Western Siberia in 2007–20112012 · 20 citations
  4. 4Rotavirus disease and vaccination: Impact on genotype diversity2009 · 320 citations
  5. 5Identification of an avian group A rotavirus containing a novel VP4 gene with a close relationship to those of mammalian rotaviruses2012 · 280 citations