Key result
Treatment with the B-NHL-BFM 2004 protocol including rituximab achieved a complete and sustained remission in a 4-year-old boy with advanced Burkitt lymphoma involving the heart.
Why the study?
Heart involvement in Burkitt lymphoma is extremely rare (2-5 %) but significantly impacts the clinical course, treatment, and follow-up.
Case Report (n=1)
Burkitt lymphoma with cardiac involvement in a pediatric patient can be successfully treated with rituximab-based chemoimmunotherapy, achieving complete remission without long-term cardiac dysfunction.
May inform management of rare pediatric Burkitt lymphoma with cardiac involvement; leaves open need for prospective data on cardiac outcomes.
Burkitt lymphoma (BL) is a highly aggressive non‑Hodgkin’s lymphoma that characterizes by affecting multiple organs and systems, which explains the diagnosis of the disease at an advanced stage upon the patient’s first medical visit. Heart involvement as part of bL dissemination is extremely rare (2–5 %), but significantly impacts the clinical course, treatment and follow‑up. Heart involvement in bL can manifest as pericardial effusion, myocardial dysfunction or subsequent development of cardiogenic shock. diagnostics of BL with heart involvement should include electrocardiography, echocardiography, N‑terminal fragment of the brain natriuretic propeptide (NT‑proBNP) blood level, myocardial damage markers (troponin I / T), and, if necessary, can include more high‑precision methods – magnetic resonance / computed tomography with intravenous contrast. Timely diagnosis and programmed treatment with rituximab can achieve long‑term survival for BL patients, including advanced stages with heart involvement.
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Radjabova et al. (2025) conducted a case report in Burkitt lymphoma with heart involvement (n=1). B-NHL-BFM 2004 protocol with rituximab was evaluated on Complete remission. Treatment with the B-NHL-BFM 2004 protocol including rituximab achieved a complete and sustained remission in a 4-year-old boy with advanced Burkitt lymphoma involving the heart.
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