Echocardiographic Findings of Malignant Lymphoma with Cardiac Involvement: A Single-center Retrospective Observational Study
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Key result
TTE detects cardiac involvement in 1.5% of malignant lymphoma patients, primarily diffuse large B-cell lymphoma.
- n=453
Why the study?
Diagnosing cardiac involvement in malignant lymphoma without cardiac manifestations is difficult.
Population
453 patients with malignant lymphoma referred to a single hospital
Design
Single-center retrospective observational study
Authors
Discussion
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Implication
Low detection rate suggests limited utility of routine TTE; hypothesis-generating for targeted screening strategies in lymphoma.
Study Design
Type
Observational (n=453)
Multicenter
No
Structured PICO
P
Population
453 patients with malignant lymphoma (ML) referred to a single center in Japan between January 2013 and December 2019, mean age 64.9 years, 54% male. Excluded: methotrexate-associated lymphoproliferative disorder.
I
Intervention
Transthoracic echocardiography (TTE) performed at initial diagnosis or during the clinical course
O
Outcome
Incidence of cardiac involvement in malignant lymphoma detected by transthoracic echocardiography
Routine transthoracic echocardiography in patients with malignant lymphoma reveals a 1.5% incidence of cardiac involvement, most commonly associated with diffuse large B-cell lymphoma and frequently presenting as pericardial effusion.
Limitations
- Single-center retrospective observational study
- Relatively small number of patients
- Patients with ML did not necessarily undergo TTE before ML treatment
- Patients did not necessarily undergo TTE before ML treatment
Cite This Study
Ebina et al. (2023) conducted an observational in Malignant lymphoma (n=453). Transthoracic echocardiography (TTE) was evaluated on Incidence of cardiac involvement detected by TTE. Cardiac involvement was detected by transthoracic echocardiography in 1.5% (6 of 394) of patients with malignant lymphoma, with diffuse large B-cell lymphoma being the most common type involved.
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