Key result
A 49-year-old male with diffuse large B-cell lymphoma and secondary cardiac involvement died after the first cycle of R-CHOP chemotherapy.
Case Report (n=1)
No
Secondary cardiac involvement from diffuse large B-cell lymphoma is a rare condition with a poor prognosis, highlighting the importance of multimodality imaging for diagnosis in disseminated disease.
Early fatality after R-CHOP in secondary cardiac DLBCL cautions on regimen safety; leaves open optimal management strategies.
The cardiac localization of metastases is a rare condition, most often found on autopsy. Lymphoma is among the primary cancers often involved, as was the case for our patient in whom cardiac involvements were discovered during the extension assessment by imaging. Clinically asymptomatic in the majority of cases, we mainly find general symptoms related to the primary disease. Because histological diagnosis is rarely possible by biopsy, confirmation is made by imaging in the context of disseminated disease. The treatment of cardiac involvements of lymphomatous origin is often medical with a poor prognosis.
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Akimana et al. (2022) conducted a case report in Diffuse Large B-cell Lymphoma with secondary cardiac involvement (n=1). R-CHOP chemotherapy was evaluated on Clinical outcome. A 49-year-old male with diffuse large B-cell lymphoma and secondary cardiac involvement died after the first cycle of R-CHOP chemotherapy.
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