Key result
Three cases of cardiac lymphoma demonstrated heterogeneous clinical behaviors, including early central nervous system relapse and challenging radiologic follow-up, requiring individualized management.
Why the study?
Cardiac lymphomas are rare extranodal lymphomas with challenging behaviors and specific peculiarities that warrant sharing and contextualizing with literature data.
Case Report (n=3)
No
Cardiac lymphoma is a rare, heterogeneous condition that requires a multidisciplinary approach for accurate diagnosis, individualized chemo-immunotherapy, and careful multimodality imaging follow-up.
Cardiac lymphoma cases flag CNS relapse risk; leaves open prophylaxis role pending larger studies.
Cardiac lymphomas are rare extranodal lymphomas involving primarily and secondarily the heart and/or pericardium. Here we describe three cases of cardiac involvement from lymphoma with specific peculiarities: two primary cardiac Diffuse Large B-cell Lymphomas and one secondary involvement from Marginal Zone Lymphoma (MZL). The first case highlights the issue of early CNS relapse and the possible role for CNS prophylaxis; the second case demonstrates the difficulties of interpretation and possible mistakes of different radiologic techniques adopted to evaluate cardiac involvement by lymphoma during follow-up; the third is a unique case of MZL with cardiac involvement. Our aim is to share the findings observed in these cases putting them in relation with data from the literature.
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Lucchini et al. (2021) conducted a case report in Cardiac involvement by lymphoma (n=3). Chemo-immunotherapy was evaluated. Three cases of cardiac lymphoma demonstrated heterogeneous clinical behaviors, including early central nervous system relapse and challenging radiologic follow-up, requiring individualized management.
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