Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2006Drugs of today

Mode of action of fibrates in the regulation of triglyceride andHDL-cholesterol metabolism

View Full Paper
Ask AI
Bookmark
Share

Design

Review

Authors

JFJean‐Charles FruchartLeiden UniversityPDPatrick DuriezUniversity of Southampton

Discussion

Loading...

Member takes

Implication

Reinforces mechanistic rationale for fibrates; leaves open their net clinical benefit in contemporary practice.

Structured PICO

I
Intervention
Fibrates (PPAR-alpha activators such as bezafibrate, fenofibrate, and gemfibrozil)

Fibrates improve lipid profiles and reduce coronary artery disease risk through PPAR-alpha-mediated regulation of lipoprotein metabolism.

Cite This Study

Fruchart et al. (2006) studied this question.

synapsesocial.com/papers/6a7b9d93169fe1af7cc28667https://doi.org/10.1358/dot.2006.42.1.963528

Topics

Coronary artery disease
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism1998 · 1,802 citations
  2. 2Hypertriglyceridemia Therapy: Past, Present and Future Perspectives2024 · 24 citations
  3. 3Hypertriglyceridemia and the fibrate trials2000 · 33 citations
  4. 4Regulation of Triglyceride Metabolism by PPARs : Fibrates and Thiazolidinediones have Distinct Effects1996 · 112 citations
  5. 5Fibrate Therapy2008 · 85 citations