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January 1, 1996Journal of Atherosclerosis and ThrombosisOpen Access

Regulation of Triglyceride Metabolism by PPARs : Fibrates and Thiazolidinediones have Distinct Effects

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Key result

Fibrates and thiazolidinediones lower triglycerides through distinct tissue-specific mechanisms, with fibrates reducing apo C-III in the liver via PPAR-alpha and thiazolidinediones inducing LPL in adipose tissue via PPAR-gamma.

Design

Review

Authors

Johan AuwerxJohan AuwerxÉcole Polytechnique Fédérale de LausanneKSKristina SchoonjansUniversity of SienaJFJean‐Charles FruchartBrigham and Women's Hospital

Discussion

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Implication

Should not change TG-lowering practice; leaves open whether distinct PPAR pathways yield differential outcomes.

Structured PICO

I
Intervention
Fibrates (PPAR alpha activators) and thiazolidinediones (PPAR gamma ligands)
O
Outcome
Regulation of lipoprotein lipase (LPL) and apolipoprotein C-III (apo C-III) gene expression and triglyceride levelssurrogate

Fibrates and thiazolidinediones exert their hypotriglyceridemic effects through distinct, tissue-specific transcriptional regulation of lipid metabolism genes via different PPAR subtypes.

Cite This Study

Auwerx et al. (1996) conducted a review in Hypertriglyceridemia. Fibrates and Thiazolidinediones was evaluated. Fibrates and thiazolidinediones lower triglycerides through distinct tissue-specific mechanisms, with fibrates reducing apo C-III in the liver via PPAR-alpha and thiazolidinediones inducing LPL in adipose tissue via PPAR-gamma.

synapsesocial.com/papers/6a90422ec63bb9fb07dd8197https://doi.org/10.5551/jat1994.3.81
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure of the human lipoprotein lipase gene1989 · 228 citations
  2. 2An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3' untranslated region polymorphisms.1993 · 227 citations
  3. 3Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression1996 · 1,220 citations
  4. 4A Human Peroxisome‐Proliferator‐Activated Receptor‐γ is Activated by Inducers of Adipogenesis, Including Thiazolidinedione Drugs1996 · 199 citations
  5. 5Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.1995 · 411 citations