Why the study?
Does combined intrarenal blockade of the renin-angiotensin system alter renal function in conscious dogs?
Population
Uninephrectomized conscious dogs in sodium balance at 10 meq/day
Comparison
Intrarenal infusion of renin inhibitor… vs Systemic infusion of the inhibitors, or…
Design
Preclinical, Inhibitors were administered individually or combined in random…
Follow-up
20 min
Authors
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Combined intrarenal RAS blockade augments renal function in conscious dogs; extends RAS physiology but leaves open human translation.
Does combined intrarenal blockade of the renin-angiotensin system alter renal function in conscious dogs?
Combined intrarenal blockade of the renin-angiotensin system significantly increases urine flow, sodium excretion, GFR, and renal plasma flow in conscious dogs, demonstrating the intrarenal RAS is a potent physiological regulator of renal function.
Siragy et al. (1990) studied this question.
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