Population
Uninephrectomized conscious dogs in metabolic balance at sodium intake of 10 meq/day
Comparison
Intrarenal administration of ACRIP at doses of… vs Baseline measurements prior to ACRIP…
Design
Preclinical
Authors
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Does not support clinical use of intrarenal renin inhibition; leaves open its angiotensin II-dependent effects on natriuresis for human validation.
Intrarenal renin inhibition increases renal sodium excretion and glomerular filtration rate through an angiotensin II-dependent mechanism, highlighting the role of intrarenal angiotensin II in fluid homeostasis.
Siragy et al. (1988) studied this question.
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