Why the study?
Does a rat renin inhibitory peptide (RRIP) suppress kidney renin synthesis in spontaneously hypertensive rats?
Does a rat renin inhibitory peptide (RRIP) suppress kidney renin synthesis in spontaneously hypertensive rats?
In spontaneously hypertensive rats, a rat renin inhibitory peptide suppressed plasma renin activity and systolic blood pressure elevation without affecting kidney renin gene expression.
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RRIP lowers BP and PRA without altering renin mRNA in rats; leaves open post-transcriptional mechanisms and human translation.
We studied the effect of a rat renin inhibitory peptide (RRIP) on kidney renin synthesis in spontaneously hypertensive rats (SHR). The RRIP was intraperitoneally administered (n=6) via an osmotic minipump to 11-week-old SHR for 7 days, at a rate of 10μg/kg/min. RRIP significantly reduced PRA and suppressed the elevation of systolic blood pressure in treated SHR compared to control. The content of kidney renin messenger RNA (mRNA) in treated SHR was comparable to that of control. Electron microscopic study revealed many renin granules and renin protogranules containing crystalline matrices in juxtaglomerular cells in RRIP-treated SHR. These results suggest that RRIP does not stimulate or suppress renin synthesis in the kidney. (Hypertens Res 1992; 15: 99-104)
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Ii et al. (1992) studied this question.
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