Why the study?
Does renin-angiotensin system inhibition alter renal bradykinin production in sodium-depleted dogs?
Population
Conscious uninephrectomized dogs in sodium metabolic balance (10 meq/day) (n=5)
Comparison
Intrarenal arterial administration of the renin… vs Baseline
Design
Preclinical
Authors
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Non-AT1 receptor mediation of renal bradykinin is suggested in this canine model; leaves open translation to human RAS therapies.
Does renin-angiotensin system inhibition alter renal bradykinin production in sodium-depleted dogs?
The renin-angiotensin system tonically stimulates renal bradykinin production and cGMP formation via a non-AT1 angiotensin receptor, and renal PGE2 production via the AT1 receptor.
Siragy et al. (1996) studied this question.
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