L1cam Expression in the Peritumoral Stromal Cells of the Microenvironment of Colorectal Cancer: A New Target for Oncologists?

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According to the seed and soil theory, also known as the Paget’s hypothesis, the tumor microenvironment (TME) plays a key role in promoting the onset and progression of cancer. In particular, fibroblasts and macrophages of the TME have been shown to regulate virtually all key tumor characteristics, from invasion to metastasis and resistance to … Continued