Population
Cultured primary rat myotubes from hindlimbs of neonatal Sprague-Dawley rats
Comparison
Ca2+-depleted medium and microtubule-depolymerizi… vs Control medium containing 1.8 mM Ca2+
Design
Preclinical
Follow-up
6 hours
Authors
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No immediate clinical implications for neuromuscular disorders; leaves open in vivo cytoskeletal roles in AChR stability.
Acetylcholine receptor clustering in cultured rat myotubes requires Ca2+ and involves cytoskeletal elements affected by microtubule-depolymerizing drugs like colchicine.
RJ Bloch (1983) studied this question.
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