Key result
Actin is associated with acetylcholine receptor domains in cultured rat myotubes, and changes in this association are accompanied by changes in the organization of isolated receptor clusters.
Population
Cultured rat myotubes and adult rat skeletal muscle
Design
Preclinical
Authors
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Supports cytoskeletal role in AChR domains; leaves open functional relevance in vivo.
This basic science study demonstrates that actin is structurally associated with acetylcholine receptor domains in muscle cells, influencing receptor cluster organization.
Robert J. Bloch (1986) studied Acetylcholine receptor clusters in cultured rat myotubes. Actin depletion and chymotrypsin digestion was evaluated on Actin association with AChR domains and cluster organization. Actin is associated with acetylcholine receptor domains in cultured rat myotubes, and changes in this association are accompanied by changes in the organization of isolated receptor clusters.
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