What is the clinical evidence from this study?

Study design: Observational. Population: Coronary artery disease requiring elective CABG (n=131). Intervention: Dual antiplatelet therapy (aspirin and clopidogrel) vs. Aspirin alone. Primary outcome: Total chest drainage during the first 48 postoperative hours (ml) (p=0.757).

January 1, 2018Medical ArchivesOpen Access

A Difference in Bleeding and Use of Blood and Blood Products in Patients who Were Preoperatively on Aspirin or Dual Antiplatelet Therapy Before Coronary Artery Bypass Grafting

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Key result

Preoperative exposure to dual antiplatelet therapy did not significantly increase total chest drainage during the first 48 postoperative hours compared to aspirin alone in patients undergoing elective CABG (1049.8 ml vs 1027.4 ml, p=0.757).

Why the study?

Does preoperative dual antiplatelet therapy compared to aspirin alone increase postoperative bleeding and the use of blood products in patients undergoing elective CABG?

Population

131 patients undergoing first-time elective on-pump isolated coronary artery bypass grafting, mean age 62.1…

Comparison

Preoperative dual antiplatelet therapy stopped… vs Preoperative aspirin alone stopped at an average…

Design

Cohort

Follow-up

48 hours postoperatively

Authors

SŠSlavenka ŠtrausUniversity of Sarajevo IHIlirijana Haxhibeqiri‐KarabdicUniversity of Sarajevo SGSanja GrabovicaUniversity of Sarajevo

Discussion

Member takes

Implication

No difference in bleeding or transfusions seen; leaves open DAPT effect on bleeding risk in elective CABG.

Study Design

Type

Observational (n=131)

Multicenter

Structured PICO

Does preoperative dual antiplatelet therapy compared to aspirin alone increase postoperative bleeding and the use of blood products in patients undergoing elective CABG?

Population

131 patients aged 41 to 81 years undergoing first-time elective on-pump isolated coronary artery bypass grafting, evaluated for postoperative bleeding over 48 hours.

Exposure

Preoperative dual antiplatelet therapy (aspirin and clopidogrel) stopped at an average of 11 days prior to surgery.

Comparator

Preoperative aspirin alone stopped at an average of 14.4 days prior to surgery.

Outcome

Postoperative bleeding (evaluated by total drainage) and use of blood and blood products in the first 48 hours postoperatively.safety

Main Result

Absolute Event Rate: 1049.76% vs 1027.44%

p-value: p=0.757

Preoperative dual antiplatelet therapy did not significantly increase postoperative bleeding or the need for blood product transfusions compared to aspirin alone in patients undergoing elective CABG.

Limitations

Retrospective observational design
Small sample size
Single-center study

Cite This Study

Štraus et al. (2018) conducted an observational in Coronary artery disease requiring elective CABG (n=131). Dual antiplatelet therapy (aspirin and clopidogrel) vs. Aspirin alone was evaluated on Total chest drainage during the first 48 postoperative hours (ml) (p=0.757). Preoperative exposure to dual antiplatelet therapy did not significantly increase total chest drainage during the first 48 postoperative hours compared to aspirin alone in patients undergoing elective CABG (1049.8 ml vs 1027.4 ml, p=0.757).

synapsesocial.com/papers/6a7bb6f77cc40aa1f8df8445 https://doi.org/10.5455/medarh.2018.72.31-35

Topics

Dual antiplatelet therapy

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A Difference in Bleeding and Use of Blood and Blood Products in Patients who Were Preoperatively on Aspirin or Dual Antiplatelet Therapy Before Coronary Artery Bypass Grafting

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

A Difference in Bleeding and Use of Blood and Blood Products in Patients who Were Preoperatively on Aspirin or Dual Antiplatelet Therapy Before Coronary Artery Bypass Grafting

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider