Key result
Dietary supplementation with 10% lemon peels, orange peels, or olive oil significantly mitigated doxorubicin-induced cardiac toxicity in rats, with olive oil providing the most substantial protection.
Why the study?
Doxorubicin induces cardiotoxicity by generating free radicals, whereas plant compounds from citrus fruits and olive oil possess antioxidant and cardioprotective properties.
Does supplementation with orange peels, lemon peels, or olive oil prevent doxorubicin-induced myocardial damage in rats?
Does supplementation with orange peels, lemon peels, or olive oil prevent doxorubicin-induced myocardial damage in rats?
p-value: p=<0.05
Lemon peels, orange peels, and olive oil mitigate doxorubicin-induced cardiotoxicity in rats by reducing oxidative stress, apoptosis, and inflammation.
May support preclinical testing of olive oil for doxorubicin cardiotoxicity; leaves open any human translation.
Background/aim Compounds originating from plants, especially citrus fruits and olive oil, have anti-inflammatory, cardioprotective, and antioxidant characteristics. Doxorubicin (DOX), an anthracycline antineoplastic, induces cardiotoxicity by generating free radicals. This study aimed to evaluate the cardioprotective effects of orange (OP) and lemon (LP) peels and olive oil (OO) against DOX-induced myocardial damage in rats. Methods Thirty adult male albino rats were randomly assigned to five groups, with six rats in each group. The control group was labeled Group I (Cnt), while Group II (DOX) got DOX intraperitoneally. Groups III, IV, and V were given a combination of DOX with OP, LP, or OO, respectively. After 28 days, cardiac biomarkers (AST, LDH, CK, cTnT), oxidative stress markers (NO, MDA), antioxidant enzyme activities (SOD, CAT, GPx), apoptotic genes ( Bax , caspase 3, Bcl2 ), NFκB and inflammatory cytokines (TNFα, IL1β) were assessed. Histopathological analysis of the heart was also conducted. Results DOX-treated rats showed significant functional and structural cardiac damage, characterized by elevated AST, LDH, CK, cTnT, NO, MDA, Bax , caspase 3, NFκB, TNFα, IL1β and reduced SOD, CAT, GPx, and Bcl2 levels. These rats exhibited myocardial necrosis, inflammatory infiltration, mitochondrial damage, and myofibril atrophy. Treatment with OP, LP, or OO mitigated these effects, with OO providing the most substantial protection. Conclusion These findings suggest that OP, LP, or OO can reduce DOX-induced cardiac toxicity by decreasing oxidative stress, apoptosis, and inflammation.
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El-Refaiy et al. (2025) studied Doxorubicin-induced myocardial damage (n=30). Lemon peels, orange peels, and olive oil vs. Doxorubicin alone was evaluated on Cardiac damage markers (AST, LDH, CK, cTnT) and histopathological changes (p=<0.05). Dietary supplementation with 10% lemon peels, orange peels, or olive oil significantly mitigated doxorubicin-induced cardiac toxicity in rats, with olive oil providing the most substantial protection.
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