The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats

Figures

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  Figure 1. The impact of various groups on CK-MB (a), LDH (b), CPK (c), and SGOT (d) levels in DOX-intoxicated ischemic rats was examined. The values are presented as mean + SEM after performing a one-way ANOVA. Comparison of the experimental groups to the disease control group yielded a significance level of p < 0.001 denoted by *** and a significance level of p < 0.01 denoted by **. Additionally, when comparing the disease control group to the control group, there was a significant difference of p < 0.001 indicated by (a).

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  Figure 2. The impact of various groups on the levels of cholesterol (a), triglycerides (b), LDL (c), and HDL (d) in DOX-intoxicated ischemic rats. The values are represented as the mean plus the standard error of the mean (SEM) when a one-way ANOVA was applied. When comparing the experimental groups to the disease control group, *** represents a p-value of less than 0.001 and ** represents a p-value of less than 0.01. Additionally, when comparing the disease control group to the control group, (a) signifies a significant difference, with a p-value of less than 0.001.

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  Figure 3. The impact of various groups on CAT (a), SOD (b), MDA (c), and GSH (d) levels in DOX-intoxicated ischemic rats was examined. The values are presented as the mean + SEM when a one-way ANOVA was utilized. In the comparisons between the experimental groups and the disease control group, *** denotes a significance level of p < 0.001, ** represents p < 0.01, and * indicates p < 0.05. Additionally, when comparing the disease control group with the control group, there was a significant difference observed in (a), with a value of p < 0.001.

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  Figure 4. The effect of different groups on eNOS (a), VEGF (b), PPAR-g (c), IL-10 (d), and NFkB1 (e) in DOX-intoxicated ischemic rats was examined. Values are presented as mean plus standard error of the mean (SEM) when a one-way ANOVA was applied. When comparing the experimental groups to the disease control group, *** signifies a p-value of less than 0.001, ** signifies a p-value of less than 0.01, and * signifies a p-value of less than 0.05. When comparing the disease control group to the control group, there is a significant difference (a, p-value of less than 0.001) with regards to eNOS.