Key result
Decreasing temperature to 34 °C reduced heart rate by 22% in vitro, while increasing to 40 °C increased heart rate by 20% and significantly decreased calcium transient amplitude.
Population
Chick embryonic heart (isolated ED4 chick hearts in vitro and in ovo)
Comparison
Acute temperature change (34, 37, and 40 °C) vs Baseline temperature (37 °C)
Design
Preclinical
Authors
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Acute temperature effects on chick embryonic cardiac calcium dynamics warrant caution in extrapolation; leaves open relevance to mammalian or clinical models.
Acute temperature changes significantly alter heart rate and calcium transients in chick embryonic hearts, with the pacemaker and AV canal being the most temperature-sensitive segments.
Vostárek et al. (2016) studied Chick embryonic heart function. Acute temperature change (34 °C and 40 °C) vs. 37 °C was evaluated on Heart rate and calcium transients. Decreasing temperature to 34 °C reduced heart rate by 22% in vitro, while increasing to 40 °C increased heart rate by 20% and significantly decreased calcium transient amplitude.
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