Key result
Shortening dual antiplatelet therapy to 3-6 months following next-generation drug-eluting stent implantation has yielded inconsistent clinical results across recent pivotal reports.
Why the study?
Does shortened dual antiplatelet therapy (3-6 months) compared to standard therapy (at least 12 months) provide optimal outcomes in patients following next-generation drug-eluting stent implantation?
Does shortened dual antiplatelet therapy (3-6 months) compared to standard therapy (at least 12 months) provide optimal outcomes in patients following next-generation drug-eluting stent implantation?
This review highlights the ongoing uncertainty and inconsistent clinical results regarding the safety and efficacy of shortening DAPT to 3-6 months after next-generation DES implantation.
Uncertainty on shortened DAPT after next-generation DES warrants caution; leaves optimal duration open for definitive trials.
Current percutaneous coronary intervention guidelines recommend dual antiplatelets (aspirin 100 mg + clopidogrel 75 mg daily) for at least 12 mo following drug-eluting stent (DES) implantation if patients are not at high risk of bleeding. Several reports have tried to shorten the dual antiplatelet therapy to 3-6 mo, especially following next-generation DES implantation, for cost-effectiveness. However, the clinical results are inconsistent and the data regarding next-generation DESs limited. In this report, recently published important pivotal reports regarding the optimal duration of dual antiplatelets following DES implantation are summarized.
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Seung‐Woon Rha (2014) conducted a review in Drug-eluting stent (DES) implantation. Dual antiplatelet therapy was evaluated. Shortening dual antiplatelet therapy to 3-6 months following next-generation drug-eluting stent implantation has yielded inconsistent clinical results across recent pivotal reports.
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