Key result
Women aged 35-84 years had a lower incidence of first stroke hospitalization than men, but women aged ≥85 years had a higher 30-day case fatality.
Why the study?
Does sex affect the incidence and 30-day case fatality of first stroke hospitalization across different age groups?
Observational
Yes
Does sex affect the incidence and 30-day case fatality of first stroke hospitalization across different age groups?
Women under 85 have a lower incidence of stroke than men, but women 85 and older face a higher 30-day case fatality rate.
Answers are grounded in this paper and cite their sources.
Supports age-stratified sex differences in stroke outcomes; extends observational data but leaves open mechanisms and targeted interventions.
BACKGROUND: Few studies have examined the impact of sex across different age groups and over time on chronic diseases in Asia. The objective of this study was to explore the effect of sex across different age groups and over time on stroke incidence and 30-day case fatality in Hong Kong. METHODS: Over 90% first hospitalizations for stroke in Hong Kong (from 2000 to 2007) were identified from the Clinical Management System of the Hospital Authority. Age-specific rate ratios (RRs; women to men) for incidence of first hospitalization and the 30-day case fatality were estimated based on Poisson regression models after adjustment for year of hospitalization. RESULTS: Women below the age of 85 years had a lower incidence of first hospitalization than men, and the effect size varied with age [35-44 years: RR = 0.56, 95% confidence interval (CI) = 0.49-0.64; 45-54 years: 0.65, 0.53-0.79; 55-64 years: 0.58, 0.48-0.71; 65-74 years: 0.71, 0.58-0.85; 75-84 years: 0.83, 0.68-1.00)]. Women aged ≥85 years had a stroke incidence similar to men, but the adjusted 30-day case fatality was significantly higher than that of men aged ≥85 years (RR = 1.14, 95% CI = 1.05-1.23). CONCLUSIONS: Lower rates of incidence were observed in women than men aged 35-84 years in Hong Kong but short-term case fatality is greater in women aged ≥85 years.
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Wu et al. (2012) conducted an observational in Stroke. Female sex vs. Male sex was evaluated on 30-day case fatality (ages ≥85 years) (RR 1.14, 95% CI 1.05-1.23). Women aged 35-84 years had a lower incidence of first stroke hospitalization than men, but women aged ≥85 years had a higher 30-day case fatality.
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