Key result
Urinary microalbumin, serum cystatin C, homocysteine, and emerging biomarkers play a crucial role in the early detection and diagnosis of diabetic nephropathy.
Why the study?
Diabetic nephropathy is a leading cause of end-stage renal disease and death in diabetic patients, prompting the need to evaluate markers and diagnostic approaches to assess renal function as early as possible.
What is the role of various biomarkers and renal biopsy in the early diagnosis and evaluation of diabetic nephropathy?
What is the role of various biomarkers and renal biopsy in the early diagnosis and evaluation of diabetic nephropathy?
This review summarizes the current landscape of traditional and emerging biomarkers for the early detection and evaluation of diabetic nephropathy.
Diabetic nephropathy (DN) is the principal consideration of end-stage diabetic nephropathy in China, second only to chronic glomerulonephritis. It is the most common complication of diabetes and the cause of death in diabetic patients. The clinical manifestations of DN are proteinuria, edema, hypertension, and progressive renal damage, and its continuous development can turn into nephrotic syndrome and uremia. It has been reported that urinary microalbumin, cystatin C and homocysteine are related to the diagnosis of renal diseases. In addition, pathological examination of renal biopsy, as the golden standard, plays a vital role in clinical diagnosis of DN. In the meantime, with the rise of biomarkers research, such as Genetic Markers, miRNAs and AGEs, we can evaluate the renal function of diabetic patients by detecting these markers as early as possible. Taking into account the above information, we focus on research advances in the association of microalbuminuria, urinary inhibitory C, serum homocysteine, renal biopsy and biomarkers with DN.
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Wang et al. (2024) conducted a review in Diabetic nephropathy. Biomarkers (urinary microalbumin, cystatin C, homocysteine, genetic markers, miRNAs, AGEs) was evaluated. Urinary microalbumin, serum cystatin C, homocysteine, and emerging biomarkers play a crucial role in the early detection and diagnosis of diabetic nephropathy.
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