Why the study?
What are the potential pre-clinical markers for the early diagnosis of diabetic nephropathy in patients with type 1 diabetes mellitus?
What are the potential pre-clinical markers for the early diagnosis of diabetic nephropathy in patients with type 1 diabetes mellitus?
Novel biomarkers and proteomic analysis may enable the diagnosis of diabetic nephropathy at a pre-clinical, potentially reversible stage before microalbuminuria develops.
Due to progressive nature of diabetic nephropathy (DN) and limited effectiveness of therapeutic efforts at clinically overt stages, diagnosisof pre-clinical (and, therefore, potentially reversible) DN is especially important. To date, however, test for microalbuminuriaremains the only technique applicable for early diagnostics of DN. Current review addresses search for potential markers of pre-clinical stage of DN in patients with type 1 diabetes mellitus and embracesdata from latest experimental and clinical studies in this area.
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Лебедева et al. (2012) studied this question.
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