Key result
Patients with Brugada syndrome had a significantly steeper maximum slope of the action potential duration restitution curve in the right ventricular outflow tract compared to controls (2.90 vs 1.38, P<0.001).
Why the study?
Do action potential duration restitution properties in the right ventricular outflow tract differ between patients with Brugada syndrome and controls?
Case-Control (n=33)
No
Do action potential duration restitution properties in the right ventricular outflow tract differ between patients with Brugada syndrome and controls?
Absolute Event Rate: 2.9% vs 1.38%
p-value: p=<0.001
Patients with Brugada syndrome exhibit a shorter effective refractory period and a steeper APD restitution curve in the RVOT, which may relate to their susceptibility to ventricular fibrillation.
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May implicate steeper RVOT APD restitution in Brugada VF susceptibility; hypothesis-generating and requires prospective validation.
Ashino et al. (2010) conducted a case-control in Brugada Syndrome (n=33). Brugada syndrome vs. Control patients without Brugada-type ECG was evaluated on Maximum slope of the APD restitution curve in the RVOT (p=<0.001). Patients with Brugada syndrome had a significantly steeper maximum slope of the action potential duration restitution curve in the right ventricular outflow tract compared to controls (2.90 vs 1.38, P<0.001).
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