Key result
In vivo high-density mapping in Brugada syndrome patients demonstrated marked regional endocardial conduction delay and reduced local activation gradient (0.33 vs 0.51 mm/ms; P<0.0005) versus controls.
Why the study?
Does in vivo high-density mapping reveal differences in right ventricular conduction and repolarization properties between Brugada syndrome patients and controls?
Case-Control (n=38)
Does in vivo high-density mapping reveal differences in right ventricular conduction and repolarization properties between Brugada syndrome patients and controls?
Absolute Event Rate: 0.33% vs 0.51%
p-value: p=<0.0005
High-density mapping reveals marked regional endocardial conduction delay and repolarization heterogeneities in the right ventricular outflow tract of Brugada syndrome patients, which appear critical for ventricular tachycardia initiation.
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Supports conduction delay as Brugada substrate; hypothesis-generating for targeted interventions pending prospective validation.
Lambiase et al. (2009) conducted a case-control in Brugada syndrome (n=38). In vivo high-density mapping vs. Controls was evaluated on Local activation gradient in the anterolateral free wall of the right ventricular outflow tract (mm/ms) (p=<0.0005). In vivo high-density mapping in Brugada syndrome patients demonstrated marked regional endocardial conduction delay and reduced local activation gradient (0.33 vs 0.51 mm/ms; P<0.0005) versus controls.
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