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June 5, 2022Medical alphabetOpen Access

Predictors of contrast-induced acute kidney injury in hemodynamically stable patients with myocardial infarction

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Key result

In hemodynamically stable patients with myocardial infarction undergoing emergency PCI, a contrast volume ≥ 145 ml was strongly associated with the development of contrast-induced acute kidney injury (OR 9.33).

Why the study?

Predictors of contrast-induced acute kidney injury in hemodynamically stable patients with myocardial infarction needed to be determined.

Population

487 hemodynamically stable MI patients after emergency PCI

Comparison

Patients who developed CI-AKI vs those without CI-AKI

Design

Observational study

Follow-up

48 hours

Authors

OAO. V. ArsenichevaIvanovo State Medical Academy

Discussion

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Implication

May aid CI-AKI risk stratification in stable post-PCI MI; leaves open prospective validation of predictors.

Study Design

Type

Observational (n=487)

Blinding

Open-label

Multicenter

No

Structured PICO

P
Population
487 hemodynamically stable patients with myocardial infarction undergoing emergency percutaneous coronary intervention, evaluated for contrast-induced acute kidney injury during their hospital stay.
O
Outcome
Contrast-induced acute kidney injury (CI-AKI), defined as an increase in the level of creatinine in the blood within 48 hours after administration of the radiopaque drug by ≥ 26.5 mmol from the baseline levelsafety

Main Result

Odds Ratio: 9.33 (95% CI 3.22–27.06)

p-value: p=<0.001

In hemodynamically stable patients with myocardial infarction undergoing emergency PCI, elevated admission glucose, higher contrast volume, and multi-stent implantation are significant predictors of contrast-induced acute kidney injury.

Limitations

  • Single-center study design
  • Relatively small number of patients who developed CI-AKI (n=48)

Cite This Study

O. V. Arsenicheva (2022) conducted an observational in Myocardial infarction (n=487). Contrast volume ≥ 145 ml vs. Contrast volume < 145 ml was evaluated on Contrast-induced acute kidney injury (CI-AKI) within 48 hours (OR 9.33, 95% CI 3.22-27.06, p=<0.001). In hemodynamically stable patients with myocardial infarction undergoing emergency PCI, a contrast volume ≥ 145 ml was strongly associated with the development of contrast-induced acute kidney injury (OR 9.33).

synapsesocial.com/papers/6a7bcb04af1d6cbe7375d120https://doi.org/10.33667/2078-5631-2022-9-31-35
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute kidney injury among ST elevation myocardial infarction patients treated by primary percutaneous coronary intervention: a multifactorial entity2016 · 72 citations
  2. 2Incidence and In‐Hospital Mortality of Acute Kidney Injury (AKI) and Dialysis‐Requiring AKI (AKI‐D) After Cardiac Catheterization in the National Inpatient Sample2016 · 40 citations
  3. 3Predictors of acute kidney injury in patients admitted with ST-elevation myocardial infarction – results from the Bremen STEMI-Registry2017 · 57 citations
  4. 4A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary interventionDevelopment and initial validation2004 · 1,276 citations
  5. 5Incidence, Outcomes, and Comparisons across Definitions of AKI in Hospitalized Individuals2013 · 453 citations