Key result
Exposure to serotonergic antidepressants was associated with an increased risk of newly diagnosed cardiac valve regurgitation (OR 3.08; 95% CI 1.35-7.04).
Why the study?
Does the use of serotonergic antidepressants increase the risk of valvular heart disease in adults without known cardiovascular disease?
Population
401 adults drawn from a cohort of 2,911 persons aged 21-58 years who underwent an echocardiogram between…
Comparison
Use of selective serotonin reuptake inhibitors… vs Non-use of serotonergic agents (control group).
Design
Case-control
Authors
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May prompt echocardiographic vigilance in long-term SSRI/SNRI users; leaves open causality pending prospective studies.
Case-Control (n=401)
No
Does the use of serotonergic antidepressants increase the risk of valvular heart disease in adults without known cardiovascular disease?
Odds Ratio: 3.08 (95% CI 1.35–7.04)
Absolute Event Rate: 11.6% vs 4.1%
The use of serotonergic antidepressants (SSRIs and SNRIs) is associated with a significantly increased risk of developing cardiac valve regurgitation in a dose-dependent manner.
Backer et al. (2016) conducted a case-control in valvular heart disease (n=401). Serotonergic antidepressants (SSRIs and SNRIs) vs. Non-use was evaluated on valvular disease (OR 3.08, 95% CI 1.35-7.04). Exposure to serotonergic antidepressants was associated with an increased risk of newly diagnosed cardiac valve regurgitation (OR 3.08; 95% CI 1.35-7.04).
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