Key result
Compared with controls, CHF patients had RR interval and BP reflex responses reduced by 36% and 54% (P<0.01), which correlated significantly with increased pulse wave velocity, not ejection fraction.
Why the study?
Is impaired baroreflex control of heart rate in congestive heart failure associated with increased pulse wave velocity rather than reduced ejection fraction?
Population
89 subjects including congestive heart failure patients, age-matched controls, and coronary artery disease…
Design
Cross-sectional
Authors
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Impaired baroreflex control in CHF was associated with PWV over EF; hypothesis-generating and requires prospective validation.
Cross-Sectional (n=89)
Is impaired baroreflex control of heart rate in congestive heart failure associated with increased pulse wave velocity rather than reduced ejection fraction?
p-value: p=<0.01
Baroreflex impairment in heart failure and coronary artery disease correlates with increased arterial stiffness (pulse wave velocity) rather than reduced ejection fraction.
Radaelli et al. (2010) conducted a cross-sectional in Congestive heart failure (n=89). Increased pulse wave velocity vs. Age-matched controls was evaluated on RR interval and BP reflex responses to neck suction (p=<0.01). Compared with controls, CHF patients had RR interval and BP reflex responses reduced by 36% and 54% (P<0.01), which correlated significantly with increased pulse wave velocity, not ejection fraction.
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