Why the study?
Does aspirin/ticlopidine or aspirin alone reduce platelet and thrombus deposition compared to aspirin/warfarin after intracoronary stenting in a porcine model?
Population
15 juvenile farm swine undergoing intracoronary stenting (30 stents deployed)
Comparison
Aspirin 325 mg/day and ticlopidine 500 mg/day… vs Aspirin 325 mg/day and warfarin 0.1 mg/kg/day
Design
Preclinical, randomized to one of 3 anticoagulation protocols
Follow-up
24 hours
Authors
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Aspirin/warfarin may increase thrombogenicity after stenting in pigs; leaves open optimal regimen in patients pending human data.
Does aspirin/ticlopidine or aspirin alone reduce platelet and thrombus deposition compared to aspirin/warfarin after intracoronary stenting in a porcine model?
In a porcine coronary stent model, aspirin plus warfarin was associated with greater thrombogenicity and platelet deposition than aspirin plus ticlopidine or aspirin alone.
Tanguay et al. (1997) studied this question.
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