Key result
Short-term administration of recombinant human growth hormone significantly increased PIIINP levels from 0.28 to 0.42 U/ml (P<0.05) in healthy males, while paradoxically improving arterial pulse wave velocity and inflammatory markers.
Why the study?
Does short-term recombinant human growth hormone administration affect PIIINP, endothelial function, and selected cardiovascular disease risk factors in healthy males?
RCT (n=48)
Single-blind
Randomly assigned
No
Does short-term recombinant human growth hormone administration affect PIIINP, endothelial function, and selected cardiovascular disease risk factors in healthy males?
Answers are grounded in this paper and cite their sources.
Short-term rhGH may warrant endothelial monitoring in hypertension; leaves open net CVD effects pending randomized trials.
Objectives: In arterial hypertension, aminoterminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean SD, age 32 11 years; height 1.8 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean SD, age 32 9 years; height 1.8 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated.
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Graham et al. (2017) conducted an RCT in Healthy males (n=48). Recombinant human growth hormone (rhGH) vs. Control group was evaluated on PIIINP levels (U/ml) (p=<0.05). Short-term administration of recombinant human growth hormone significantly increased PIIINP levels from 0.28 to 0.42 U/ml (P<0.05) in healthy males, while paradoxically improving arterial pulse wave velocity and inflammatory markers.
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