What question did this study set out to answer?

To measure and characterize the turnover, lifespan, and consumption dynamics of platelets and fibrinogen in human circulation.

January 1, 1973Critical Care Medicine

Platelet and fibrinogen consumption in man

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Authors

LHLaurence A. HarkerOpole University of Technology SSSHERILL J. SLICHTERUniversity of Washington

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Implication

Clinical investigation demonstrates platelet and fibrinogen consumption kinetics in humans, highlighting mechanisms governing intravascular coagulation.

Key Points

To measure and characterize the turnover, lifespan, and consumption dynamics of platelets and fibrinogen in human circulation.
Evaluated platelet and fibrinogen kinetics and clearance rates in human subjects under clinical conditions.
Demonstrated measurable consumption patterns of platelets alongside fibrinogen, establishing physiological baselines for human clotting factor utilization.

Cite This Study

Harker et al. (1973) studied this question.

synapsesocial.com/papers/6a7be1541f8f1eb7b8ed3cde https://doi.org/10.1097/00003246-197301000-00012

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Implication

Clinical investigation demonstrates platelet and fibrinogen consumption kinetics in humans, highlighting mechanisms governing intravascular coagulation.

Platelet and fibrinogen consumption in man

Discussion

Member takes

Implication

Key Points

Cite This Study

Platelet and fibrinogen consumption in man

Discussion

Member takes

Implication

Key Points

Cite This Study

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