Key result
A nutraceutical mixture improved body weight and food consumption, reduced oxidative stress, and preserved liver and heart structure in rats treated with doxorubicin.
Why the study?
Doxorubicin causes unpleasant side effects, prompting evaluation of whether a specific antioxidant, antiproliferative, and anti-inflammatory dietary mixture could exert protective effects against doxorubicin toxicity.
Does a nutraceutical mixture reduce doxorubicin-induced toxicity in a rat model?
RCT (n=30)
randomized
Does a nutraceutical mixture reduce doxorubicin-induced toxicity in a rat model?
A specific nutraceutical mixture protects against doxorubicin-induced structural damage and oxidative stress in the heart and liver of rats.
Should not yet change doxorubicin regimens; leaves open whether botanical mixtures confer clinical cardioprotection.
The antibiotic doxorubicin is often used as an anti-neoplastic drug; however, many patients showed very unpleasant side-effects. Previous studies have demonstrated that dietary substances such as Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus may have anti-oxidant, anti-proliferative, and anti-inflammatory effects. The purpose of this study was to investigate the protective effects of a mixture of these components in an experimental model of doxorubicin toxicity. Rats (n = 30) received doxorubicin (5 mg/kg/day) for 4 weeks and were randomized to receive the dietary mixture 2 hours following the first doxorubicin injection and until the end of the experiment. Animals were killed following 4 weeks, and blood, liver, and heart were collected for further analysis. The dietary supplement improved the depressed body weight and food consumption induced by DOX. In addition, the nutraceutical mixture reduced oxidative stress, ameliorated the morphological score, and preserved liver and heart structure, demonstrating a protective effect. These data show for the first time that the mixture of Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus may be useful to reduce the side effects following treatment with doxorubicin, and might ameliorate the quality of life of patients following chemotherapy.
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Irrera et al. (2019) conducted an RCT in doxorubicin toxicity (n=30). Nutraceutical mixture (Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus) vs. doxorubicin alone was evaluated on body weight, food consumption, oxidative stress, morphological score, and liver/heart structure. A nutraceutical mixture improved body weight and food consumption, reduced oxidative stress, and preserved liver and heart structure in rats treated with doxorubicin.
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