Key result
Rheumatoid arthritis was associated with significantly higher rates of elevated high-sensitivity cardiac troponin T (7% vs 1%) and NT-proBNP (16% vs 4%) compared to healthy controls, independent of traditional cardiovascular risk factors.
Population
236 unrelated patients with rheumatoid arthritis and 213 age-matched and sex-matched healthy controls.
Design
Case-control
Authors
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May indicate subclinical cardiac stress in RA; hypothesis-generating and requires prospective validation before informing practice.
Cross-Sectional (n=449)
Single-blind
Yes
Absolute Event Rate: 7% vs 1%
p-value: p=0.003
Patients with rheumatoid arthritis have elevated levels of cardiac biomarkers (HS-cTnT and NT-proBNP) independent of traditional cardiovascular risk factors, suggesting a link between systemic inflammation and subclinical myocardial injury.
Avouac et al. (2013) conducted a cross-sectional in Rheumatoid arthritis (n=449). Rheumatoid arthritis vs. Healthy controls was evaluated on Elevated high-sensitivity cardiac troponin T (HS-cTnT > 14 ng/l) (p=0.003). Rheumatoid arthritis was associated with significantly higher rates of elevated high-sensitivity cardiac troponin T (7% vs 1%) and NT-proBNP (16% vs 4%) compared to healthy controls, independent of traditional cardiovascular risk factors.
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