Key result
Repeated measures of C-reactive protein were independently and linearly associated with NT-proBNP levels over a 10-year follow-up in patients with rheumatoid arthritis (p<0.001).
Population
238 patients with rheumatoid arthritis of less than 4 years in duration, mean age 51.6 years, 73.5% female…
Design
Cohort
Follow-up
10 years
Authors
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May link inflammation to cardiac stress in RA; hypothesis-generating and requires trials to assess causality or utility.
Cohort (n=238)
Effect estimate: β coefficient 1.01 (95% CI 1.01-1.02)
p-value: p=<0.001
In patients with early rheumatoid arthritis, C-reactive protein levels are independently associated with NT-proBNP levels in both cross-sectional and longitudinal analyses over 10 years, suggesting a link between systemic inflammation and cardiovascular stress.
Provan et al. (2008) conducted a cohort in Rheumatoid arthritis (n=238). C-reactive protein (CRP) levels vs. Lower CRP levels was evaluated on NT-proBNP levels (β coefficient 1.01, 95% CI 1.01-1.02, p=<0.001). Repeated measures of C-reactive protein were independently and linearly associated with NT-proBNP levels over a 10-year follow-up in patients with rheumatoid arthritis (p<0.001).
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