Why the study?
Does cyclosporine reduce mortality in a murine viral myocarditis model?
Population
98 mice with viral myocarditis (murine viral myocarditis model)
Comparison
Cyclosporine vs Infected control group
Design
Preclinical
Follow-up
15 days
Authors
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May increase early mortality in viral myocarditis models; challenges assumptions and leaves open human translation.
Does cyclosporine reduce mortality in a murine viral myocarditis model?
Cyclosporine use in the early stages of viral myocarditis in mice enhanced anti-heart autoantibody production and was associated with a higher mortality rate.
Matoba et al. (1991) studied this question.
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