Key result
Early prednisolone or cyclosporine aggravates viral myocarditis in mice and provides no recovery benefit.
Why the study?
The immunopathogenesis of viral myocarditis and the effects of immunosuppressive treatment in this condition were not fully understood.
Does immunosuppressive treatment with prednisolone or cyclosporine improve the course of viral myocarditis in a murine model?
Population
Mice with encephalomyocarditis (EMC) virus myocarditis
Comparison
Prednisolone or cyclosporine treatment versus no immunosuppressive treatment
Design
Experimental animal model study
Authors
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Early immunosuppression aggravates murine viral myocarditis; leaves open any human role and cautions against clinical use.
Does immunosuppressive treatment with prednisolone or cyclosporine improve the course of viral myocarditis in a murine model?
Immunosuppressive treatment with prednisolone or cyclosporine in the early stages of viral myocarditis aggravates the disease course in a murine model.
Matsumori et al. (1989) studied Viral myocarditis. Prednisolone and cyclosporine was evaluated on Disease course. Prednisolone or cyclosporine given in the early stage of viral myocarditis in mice aggravated the disease course and showed no beneficial effects during the early recovery period.
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