Why the study?
Does the severity of acute oxaliplatin-induced peripheral neuropathy predict the development of chronic neuropathy in patients with metastatic colorectal cancer?
Population
170 patients with metastatic colorectal cancer scheduled to receive either combined leucovorin…
Design
Cohort
Authors
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Acute OXLIPN symptom count may identify patients at risk for chronic neuropathy; hypothesis-generating and requires prospective validation before guiding therapy.
Does the severity of acute oxaliplatin-induced peripheral neuropathy predict the development of chronic neuropathy in patients with metastatic colorectal cancer?
In patients receiving oxaliplatin for colorectal cancer, the severity of acute neuropathy symptoms strongly predicts the development and severity of chronic cumulative neuropathy.
Argyriou et al. (2012) studied this question.
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