Why the study?
Does propylthiouracil treatment improve QTc dispersion and pulmonary hypertension in patients with newly diagnosed overt hyperthyroidism?
Population
47 patients with newly diagnosed overt hyperthyroidism and 20 healthy controls
Comparison
Propylthiouracil treatment to achieve euthyroid… vs Healthy controls and pre-treatment baseline
Design
Cohort
Follow-up
until achievement of euthyroid state
Authors
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May support treating hyperthyroidism to reduce QTc dispersion and PASP; hypothesis-generating for outcomes pending randomized confirmation.
Does propylthiouracil treatment improve QTc dispersion and pulmonary hypertension in patients with newly diagnosed overt hyperthyroidism?
Hyperthyroidism is a reversible cause of pulmonary hypertension and increased QTc dispersion, which normalize upon achieving a euthyroid state.
Güntekin et al. (2009) studied this question.
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