January 1, 2015Korean Journal of PediatricsOpen Access

The corrected QT (QTc) prolongation in hyperthyroidism and the association of thyroid hormone with the QTc interval

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Why the study?

Does hyperthyroidism increase the QTc interval in young patients?

Population

110 subjects, including 38 patients with hyperthyroidism and 72 age-matched controls with no…

Comparison

Hyperthyroidism vs Age-matched patients with no hyperthyroidism

Design

Case-control

Authors

YLYe Seung LeeHallym University JCJoong Wan ChoiHallym University EBEun Ju BaeBiocon (Switzerland)

Discussion

Member takes

Implication

May warrant QTc monitoring in hyperthyroid youth; leaves open arrhythmic risk and requires prospective confirmation.

Structured PICO

Does hyperthyroidism increase the QTc interval in young patients?

Population

110 subjects, including 38 patients with hyperthyroidism (<30 years old) and 72 age-matched controls with no hyperthyroidism. Excluded patients with hypokalemia or taking drugs that interfere with the cardiovascular system (e.g., propranolol).

Intervention

Hyperthyroidism (assessment of serum free thyroxine [fT4] and thyroid stimulating hormone [TSH] levels)

Comparator

Age-matched patients with no hyperthyroidism

Outcome

QTc interval duration and frequency of QTc prolongationsurrogate

Hyperthyroidism is associated with QTc prolongation, and higher free T4 levels correlate with longer QTc intervals, suggesting an increased risk of ventricular arrhythmias.

Limitations

Relatively small number of patients with a limited age
Could not exclude the possibility that prolonged QTc interval was already present in some of the hyperthyroid patients before they developed hyperthyroidism
Free T3 levels were not available

Cite This Study

Lee et al. (2015) studied this question.

synapsesocial.com/papers/6a968e38dbc641e6a0a6c865 https://doi.org/10.3345/kjp.2015.58.7.263

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The corrected QT (QTc) prolongation in hyperthyroidism and the association of thyroid hormone with the QTc interval

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The corrected QT (QTc) prolongation in hyperthyroidism and the association of thyroid hormone with the QTc interval

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider